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The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of Pluronic ® F-127 Gel Formulations with Ketoconazole.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 20; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 20. - Publication Year :
- 2021
-
Abstract
- Fungal skin infections are currently a major clinical problem due to their increased occurrence and drug resistance. The treatment of fungal skin infections is based on monotherapy or polytherapy using the synergy of the therapeutic substances. Tea tree oil (TTO) may be a valuable addition to the traditional antifungal drugs due to its antifungal and anti-inflammatory activity. Ketoconazole (KTZ) is an imidazole antifungal agent commonly used as a treatment for dermatological fungal infections. The use of hydrogels and organogel-based formulations has been increasing for the past few years, due to the easy method of preparation and long-term stability of the product. Therefore, the purpose of this study was to design and characterize different types of Pluronic <superscript>®</superscript> F-127 gel formulations containing KTZ and TTO as local delivery systems that can be applied in cases of skin fungal infections. The influence of TTO addition on the textural, rheological, and bioadhesive properties of the designed formulations was examined. Moreover, the in vitro release of KTZ, its permeation through artificial skin, and antifungal activity by the agar diffusion method were performed. It was found that obtained gel formulations were non-Newtonian systems, showing a shear-thinning behaviour and thixotropic properties with adequate textural features such as hardness, compressibility, and adhesiveness. Furthermore, the designed preparations with TTO were characterized by beneficial bioadhesive properties. The presence of TTO improved the penetration and retention of KTZ through the artificial skin membrane and this effect was particularly visible in hydrogel formulation. The developed gels containing TTO can be considered as favourable formulations in terms of drug release and antifungal activity.
- Subjects :
- Adhesiveness
Animals
Antifungal Agents chemistry
Candida parapsilosis drug effects
Chemistry, Pharmaceutical
Drug Liberation
Ketoconazole chemistry
Kinetics
Lecithins chemistry
Mice
Microscopy, Electron, Scanning
Models, Biological
Models, Theoretical
Rheology
Skin metabolism
Antifungal Agents pharmacology
Gels chemistry
Ketoconazole pharmacology
Poloxamer chemistry
Tea Tree Oil chemistry
Tea Tree Oil pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34768755
- Full Text :
- https://doi.org/10.3390/ijms222111326