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Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height.
- Source :
-
Journal of clinical medicine [J Clin Med] 2021 Oct 27; Vol. 10 (21). Date of Electronic Publication: 2021 Oct 27. - Publication Year :
- 2021
-
Abstract
- Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe.<br />Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children.<br />Methods: A retrospective descriptive study of patients treated in the last 14 years for IGHD (Group A), in comparison with ISS-treated (Group B) and untreated (Group C) subjects.<br />Results: Group A had 67 males, who showed a height gain of 1.24 SD. Group B had 30 boys, who showed a height gain of 1.47 SD. Group C had 42 boys, who showed an improvement of 0.37 SD. The final heights were -1.52 SD, -1.31 SD, and -2.03 SD, respectively. Group A and C did not reach their target heights (with differences of 0.27 SD and 0.59 SD, respectively). Group B surpassed their target height by 0.29 SD.<br />Conclusions: The final heights of the IGHD and treated ISS are similar. Treated groups were taller than untreated groups.
Details
- Language :
- English
- ISSN :
- 2077-0383
- Volume :
- 10
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Journal of clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34768508
- Full Text :
- https://doi.org/10.3390/jcm10214988