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Advancing Adjuvants for Mycobacterium tuberculosis Therapeutics.

Authors :
Enriquez AB
Izzo A
Miller SM
Stewart EL
Mahon RN
Frank DJ
Evans JT
Rengarajan J
Triccas JA
Source :
Frontiers in immunology [Front Immunol] 2021 Oct 25; Vol. 12, pp. 740117. Date of Electronic Publication: 2021 Oct 25 (Print Publication: 2021).
Publication Year :
2021

Abstract

Tuberculosis (TB) remains one of the leading causes of death worldwide due to a single infectious disease agent. BCG, the only licensed vaccine against TB, offers limited protection against pulmonary disease in children and adults. TB vaccine research has recently been reinvigorated by new data suggesting alternative administration of BCG induces protection and a subunit/adjuvant vaccine that provides close to 50% protection. These results demonstrate the need for generating adjuvants in order to develop the next generation of TB vaccines. However, development of TB-targeted adjuvants is lacking. To help meet this need, NIAID convened a workshop in 2020 titled "Advancing Vaccine Adjuvants for Mycobacterium tuberculosis Therapeutics". In this review, we present the four areas identified in the workshop as necessary for advancing TB adjuvants: 1) correlates of protective immunity, 2) targeting specific immune cells, 3) immune evasion mechanisms, and 4) animal models. We will discuss each of these four areas in detail and summarize what is known and what we can advance on in order to help develop more efficacious TB vaccines.<br />Competing Interests: Author RNM was employed by company Columbus Technologies & Services Inc. JE and SM are employees of and own shares in Inimmune Corporation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Enriquez, Izzo, Miller, Stewart, Mahon, Frank, Evans, Rengarajan and Triccas.)

Details

Language :
English
ISSN :
1664-3224
Volume :
12
Database :
MEDLINE
Journal :
Frontiers in immunology
Publication Type :
Academic Journal
Accession number :
34759923
Full Text :
https://doi.org/10.3389/fimmu.2021.740117