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Intrinsic network activity reflects the ongoing experience of chronic pain.
- Source :
-
Scientific reports [Sci Rep] 2021 Nov 08; Vol. 11 (1), pp. 21870. Date of Electronic Publication: 2021 Nov 08. - Publication Year :
- 2021
-
Abstract
- Analyses of intrinsic network activity have been instrumental in revealing cortical processes that are altered in chronic pain patients. In a novel approach, we aimed to elucidate how intrinsic functional networks evolve in regard to the fluctuating intensity of the experience of chronic pain. In a longitudinal study with 156 fMRI sessions, 20 chronic back pain patients and 20 chronic migraine patients were asked to continuously rate the intensity of their endogenous pain. We investigated the relationship between the fluctuation of intrinsic network activity with the time course of subjective pain ratings. For chronic back pain, we found increased cortical network activity for the salience network and a local pontine network, as well as decreased network activity in the anterior and posterior default mode network for higher pain intensities. Higher pain intensities in chronic migraine were accompanied with lower activity in a prefrontal cortical network. By taking the perspective of the individual, we focused on the variability of the subjective perception of pain, which include phases of relatively low pain and phases of relatively high pain. The present design of the assessment of ongoing endogenous pain can be a powerful and promising tool to assess the signature of a patient's endogenous pain encoding.<br /> (© 2021. The Author(s).)
- Subjects :
- Adult
Back Pain diagnostic imaging
Back Pain physiopathology
Brain Mapping
Cerebral Cortex diagnostic imaging
Cerebral Cortex physiopathology
Chronic Pain diagnostic imaging
Female
Functional Neuroimaging
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Migraine Disorders diagnostic imaging
Migraine Disorders physiopathology
Nerve Net diagnostic imaging
Nerve Net physiopathology
Neural Pathways diagnostic imaging
Neural Pathways physiopathology
Pain Measurement
Pain Perception physiology
Prefrontal Cortex diagnostic imaging
Prefrontal Cortex physiopathology
Young Adult
Chronic Pain physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34750460
- Full Text :
- https://doi.org/10.1038/s41598-021-01340-0