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Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease.
- Source :
-
Trends in molecular medicine [Trends Mol Med] 2022 Jan; Vol. 28 (1), pp. 8-11. Date of Electronic Publication: 2021 Nov 05. - Publication Year :
- 2022
-
Abstract
- Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows that defects in FAP function contributes to chronic muscle diseases and targeting FAPs offers avenues for treating these diseases.<br />Competing Interests: Declaration of interests No interests to declare.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1471-499X
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Trends in molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34750068
- Full Text :
- https://doi.org/10.1016/j.molmed.2021.10.003