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The Ontogeny and Function of Placental Macrophages.

Authors :
Thomas JR
Naidu P
Appios A
McGovern N
Source :
Frontiers in immunology [Front Immunol] 2021 Oct 21; Vol. 12, pp. 771054. Date of Electronic Publication: 2021 Oct 21 (Print Publication: 2021).
Publication Year :
2021

Abstract

The placenta is a fetal-derived organ whose function is crucial for both maternal and fetal health. The human placenta contains a population of fetal macrophages termed Hofbauer cells. These macrophages play diverse roles, aiding in placental development, function and defence. The outer layer of the human placenta is formed by syncytiotrophoblast cells, that fuse to form the syncytium. Adhered to the syncytium at sites of damage, on the maternal side of the placenta, is a population of macrophages termed placenta associated maternal macrophages (PAMM1a). Here we discuss recent developments that have led to renewed insight into our understanding of the ontogeny, phenotype and function of placental macrophages. Finally, we discuss how the application of new technologies within placental research are helping us to further understand these cells.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Thomas, Naidu, Appios and McGovern.)

Details

Language :
English
ISSN :
1664-3224
Volume :
12
Database :
MEDLINE
Journal :
Frontiers in immunology
Publication Type :
Academic Journal
Accession number :
34745147
Full Text :
https://doi.org/10.3389/fimmu.2021.771054