Visible Light-Promoted Radical Relay Cyclization/C-C Bond Formation of N -Allylbromodifluoroacetamides with Quinoxalin-2(1 H )-ones.

A visible light-promoted radical relay of N -allylbromodifluoroacetamide with quinoxalin-2(1 H )-ones was developed in which 5- exo - trig cyclization and C-C bond formation were involved. This protocol was performed under mild conditions to facilely offer a variety of hybrid molecules bearing both quinoxalin-2(1 H )-one and 3,3-difluoro-γ-lactam motifs. These prepared novel skeletons would expand the accessible chemical space for structurally complex heterocycles with potential biological activities.