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Chromogranin A (CgA) as a biomarker in carcinoid heart disease and NETG1/G2 neuroendocrine neoplasms of the small intestine (SI-NENs) related carcinoid syndrome.
- Source :
-
Medicina clinica [Med Clin (Barc)] 2022 Jul 22; Vol. 159 (2), pp. 85-89. Date of Electronic Publication: 2021 Nov 01. - Publication Year :
- 2022
-
Abstract
- Introduction: Progression of carcinoid syndrome (CS) to carcinoid heart disease (CHD) is difficult to predict. This retrospective analysis evaluates the use of chromogranin A (CgA), a biomarker widely used in the diagnosis of neuroendocrine tumours (NET), in monitoring CS and disease progression.<br />Patients and Methods: 108 patients with confirmed CS, selected from a group of 351 patients with neuroendocrine neoplasms of the small intestine (SI-NENs), including NETG1 well 40% and NETG2 60% moderately differentiated NET. CgA concentration was measured during initial diagnosis and clinical follow up in 84 patients, 27 of them subsequently developed CHD. The patient's overall survival (OS) was evaluated using the Kaplan-Meier method.<br />Results: Patients with CHD, were found to have significantly shorter OS than patients with CS but without CHD (67.22 vs. 73.03 months). Univariate and multivariate analyses revealed that initial high concentration of CgA and/or increased concentration of CgA is significantly associated with decreased median OS in patients with CS (p<0.05).<br />Conclusion: CgA has potential as a clinically useful biomarker in reporting disease status and predicting outcome in patients with CS and with CHD.<br /> (Copyright © 2021 Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Biomarkers
Biomarkers, Tumor
Chromogranin A
Humans
Intestine, Small pathology
Retrospective Studies
Carcinoid Heart Disease complications
Carcinoid Heart Disease diagnosis
Neuroendocrine Tumors complications
Neuroendocrine Tumors diagnosis
Neuroendocrine Tumors pathology
Pancreatic Neoplasms diagnosis
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1578-8989
- Volume :
- 159
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Medicina clinica
- Publication Type :
- Report
- Accession number :
- 34736622
- Full Text :
- https://doi.org/10.1016/j.medcli.2021.06.029