Upregulation of leukemia-induced non-coding activator RNA (LUNAR1) predicts poor outcome in pediatric T-acute lymphoblastic leukemia.

Authors :: El-Khazragy N
Abdel Aziz MA
Hesham M
Matbouly S
Mostafa SA
Bakkar A
Abouelnile M
Noufal Y
Mahran NA
Abd Elkhalek MA
Abdelmaksoud MF
Source :: Immunobiology [Immunobiology] 2021 Nov; Vol. 226 (6), pp. 152149. Date of Electronic Publication: 2021 Oct 26.
Publication Year :: 2021
Abstract: T-cell Acute Lymphoblastic Leukemia (T-ALL) accounts for around 10-15% of all lymphoblastic leukemia in children. Previous studies have proven that dysregulation of Leukemia-induced non-coding activator RNA-1 (LUNAR1) expression promotes T-ALL cell growth by enhancing the NOTCH1/IGF-1R signaling pathway. We aimed to investigate the prognostic value of LUNAR1 in pediatric T-ALL, in addition, to find out its association with NOTCH1 and IGF-1R. The LUNAR1, NOTCH1, and IGF-IR gene expression were measured in peripheral blood (PB) samples of l85 children with T-ALL and forty non-leukemic samples as a control group. Cox regression analysis revealed that overexpression of LUNAR1, NOTCH1, and IGF-IR was significantly correlated with poor prognosis, short overall survival, and progression-free survival. We concluded that LUNAR1 could serve as an independent prognostic biomarker for T-ALL in children.<br /> (Copyright © 2021 Elsevier GmbH. All rights reserved.)

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