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Catalytic and photoresponsive BiZ/Cu x S heterojunctions with surface vacancies for the treatment of multidrug-resistant clinical biofilm-associated infections.
- Source :
-
Nanoscale [Nanoscale] 2021 Nov 18; Vol. 13 (44), pp. 18632-18646. Date of Electronic Publication: 2021 Nov 18. - Publication Year :
- 2021
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Abstract
- We report a one-pot facile synthesis of highly photoresponsive bovine serum albumin (BSA) templated bismuth-copper sulfide nanocomposites (BSA-BiZ/Cu <subscript> x </subscript> S NCs, where BiZ represents in situ formed Bi <subscript>2</subscript> S <subscript>3</subscript> and bismuth oxysulfides (BOS)). As-formed surface vacancies and BiZ/Cu <subscript> x </subscript> S heterojunctions impart superior catalytic, photodynamic and photothermal properties. Upon near-infrared (NIR) irradiation, the BSA-BiZ/Cu <subscript> x </subscript> S NCs exhibit broad-spectrum antibacterial activity, not only against standard multidrug-resistant (MDR) bacterial strains but also against clinically isolated MDR bacteria and their associated biofilms. The minimum inhibitory concentration of BSA-BiZ/Cu <subscript> x </subscript> S NCs is 14-fold lower than that of BSA-Cu <subscript> x </subscript> S NCs because their multiple heterojunctions and vacancies facilitated an amplified phototherapeutic response. As-prepared BSA-BiZ/Cu <subscript> x </subscript> S NCs exhibited substantial biofilm inhibition (90%) and eradication (>75%) efficiency under NIR irradiation. Furthermore, MRSA-infected diabetic mice were immensely treated with BSA-BiZ/Cu <subscript> x </subscript> S NCs coupled with NIR irradiation by destroying the mature biofilm on the wound site, which accelerated the wound healing process via collagen synthesis and epithelialization. We demonstrate that BSA-BiZ/Cu <subscript> x </subscript> S NCs with superior antimicrobial activity and high biocompatibility hold great potential as an effective photosensitive agent for the treatment of biofilm-associated infections.
Details
- Language :
- English
- ISSN :
- 2040-3372
- Volume :
- 13
- Issue :
- 44
- Database :
- MEDLINE
- Journal :
- Nanoscale
- Publication Type :
- Academic Journal
- Accession number :
- 34734624
- Full Text :
- https://doi.org/10.1039/d1nr06358h