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Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Nov 23; Vol. 57 (93), pp. 12476-12479. Date of Electronic Publication: 2021 Nov 23. - Publication Year :
- 2021
-
Abstract
- We identified small-molecule enhancers of cellular stress granules by observing molecular crowding of proteins and RNAs in a time-dependent manner. Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(I:C) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation. Thus, modulating multimolecular crowding can be a promising strategy against SARS-CoV-2.
- Subjects :
- Animals
Antiviral Agents chemistry
Benzopyrans chemistry
Cell Line, Tumor
Chlorocebus aethiops
Cytoplasmic Granules metabolism
Dose-Response Relationship, Drug
Drug Combinations
Humans
Interferon Regulatory Factor-3 metabolism
Lopinavir pharmacology
Microbial Sensitivity Tests
Molecular Structure
Poly I-C pharmacology
Pyrazoles chemistry
Structure-Activity Relationship
Vero Cells
Antiviral Agents pharmacology
Benzopyrans pharmacology
Cytoplasmic Granules drug effects
Pyrazoles pharmacology
SARS-CoV-2 drug effects
Virus Replication drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 93
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34734602
- Full Text :
- https://doi.org/10.1039/d1cc05508a