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Angiosarcoma of the Uterus: A Systematic Review.

Authors :
Deb PQ
Weiss RE
Heller DS
Source :
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists [Int J Gynecol Pathol] 2022 Sep 01; Vol. 41 (5), pp. 496-502. Date of Electronic Publication: 2021 Oct 29.
Publication Year :
2022

Abstract

Primary uterine angiosarcoma is an extremely rare neoplasm. Due to its rarity, knowledge regarding this malignancy is limited to a few scattered case reports. To better understand the prognostic factors and optimal management of these neoplasms, we have performed a systematic analysis of the disease. A systematic literature search of this entity yielded 25 reported cases of this entity. In addition, we searched the National Cancer Institute Surveillance, Epidemiology, and End Results database to find 4 additional cases and added a case diagnosed in our institution. We analyzed the patients' demographic characteristics and the different treatment protocols utilized to treat this malignancy. Patients were primarily treated by surgery with or without adjuvant chemotherapy and radiotherapy. Survival analysis was performed to examine the role of various factors in the outcome for the patients. There was no correlation with age of diagnosis, or treatment modality used, however, better outcomes were seen in patients presenting with smaller sized tumors. Our study is the first attempt to systematically study this rare malignancy in hopes of leading to a more standardized, evidence-based, and improved treatment protocol.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2021 by the International Society of Gynecological Pathologists.)

Details

Language :
English
ISSN :
1538-7151
Volume :
41
Issue :
5
Database :
MEDLINE
Journal :
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
Publication Type :
Academic Journal
Accession number :
34723849
Full Text :
https://doi.org/10.1097/PGP.0000000000000833