Anti-NMDA Receptor Encephalitis in a Patient with Tuberous Sclerosis-Related Brain Tumor: A Case Report.

Authors :: Ihl T
Arlt FA
Machule ML
Prüss H
Audebert HJ
Source :: Case reports in neurology [Case Rep Neurol] 2021 Sep 30; Vol. 13 (3), pp. 656-663. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
Publication Year :: 2021
Abstract: Anti-NMDA receptor (NMDAR) encephalitis (NMDARE) is an important treatable cause of autoimmune psychosis in all age-groups, which is sometimes associated with tumors, especially ovarian teratomas. Tuberous sclerosis complex (TSC) is an autosomal dominant inherited neurocutaneous disease predisposing for development of benign tumors. We present a case of a 35-year-old woman with recurrent episodes of schizophrenia-like symptoms. Accidentally, MRI revealed TSC-related brain tumors. NMDAR antibody titers were strongly positive in serum and cerebrospinal fluid. This is the first case describing an overlap of NMDARE and TSC-related brain tumors. A review of brain tumors and NMDARE is given in the supplementary material. Although a causal link seems interesting from a pathophysiological point of view, we are in favor of a coincidence.<br />Competing Interests: The authors confirm that this article content has no conflict of interest.<br /> (Copyright © 2021 by S. Karger AG, Basel.)

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