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Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
- Source :
-
Nature communications [Nat Commun] 2021 Oct 29; Vol. 12 (1), pp. 6233. Date of Electronic Publication: 2021 Oct 29. - Publication Year :
- 2021
-
Abstract
- Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10 <superscript>-8</superscript> ; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10 <superscript>-10</superscript> ; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).<br /> (© 2021. The Author(s).)
- Subjects :
- Aldehyde Reductase genetics
Case-Control Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Leukemia, Myeloid, Acute mortality
Middle Aged
Reproducibility of Results
White People genetics
HLA Antigens genetics
Leukemia, Myeloid, Acute genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 34716350
- Full Text :
- https://doi.org/10.1038/s41467-021-26551-x