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A genetic model for the secretory stage of dental enamel formation.
- Source :
-
Journal of structural biology [J Struct Biol] 2021 Dec; Vol. 213 (4), pp. 107805. Date of Electronic Publication: 2021 Oct 27. - Publication Year :
- 2021
-
Abstract
- The revolution in genetics has rapidly increased our knowledge of human and mouse genes that are critical for the formation of dental enamel and helps us understand how enamel evolved. In this graphical review we focus on the roles of 41 genes that are essential for the secretory stage of amelogenesis when characteristic enamel mineral ribbons initiate on dentin and elongate to expand the enamel layer to the future surface of the tooth. Based upon ultrastructural analyses of genetically modified mice, we propose a molecular model explaining how a cell attachment apparatus including collagen 17, α6ß4 and αvß6 integrins, laminin 332, and secreted enamel proteins could attach to individual enamel mineral ribbons and mold their cross-sectional dimensions as they simultaneously elongate and orient them in the direction of the retrograde movement of the ameloblast membrane.<br /> (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Ameloblasts cytology
Ameloblasts ultrastructure
Animals
Collagen genetics
Collagen metabolism
Dental Enamel cytology
Dental Enamel Proteins metabolism
Humans
Integrins genetics
Integrins metabolism
Laminin genetics
Laminin metabolism
Mice
Microscopy, Electron, Scanning methods
Ameloblasts metabolism
Amelogenesis genetics
Dental Enamel metabolism
Dental Enamel Proteins genetics
Models, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1095-8657
- Volume :
- 213
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of structural biology
- Publication Type :
- Academic Journal
- Accession number :
- 34715329
- Full Text :
- https://doi.org/10.1016/j.jsb.2021.107805