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A genetic model for the secretory stage of dental enamel formation.

Authors :
Simmer JP
Hu JC
Hu Y
Zhang S
Liang T
Wang SK
Kim JW
Yamakoshi Y
Chun YH
Bartlett JD
Smith CE
Source :
Journal of structural biology [J Struct Biol] 2021 Dec; Vol. 213 (4), pp. 107805. Date of Electronic Publication: 2021 Oct 27.
Publication Year :
2021

Abstract

The revolution in genetics has rapidly increased our knowledge of human and mouse genes that are critical for the formation of dental enamel and helps us understand how enamel evolved. In this graphical review we focus on the roles of 41 genes that are essential for the secretory stage of amelogenesis when characteristic enamel mineral ribbons initiate on dentin and elongate to expand the enamel layer to the future surface of the tooth. Based upon ultrastructural analyses of genetically modified mice, we propose a molecular model explaining how a cell attachment apparatus including collagen 17, α6ß4 and αvß6 integrins, laminin 332, and secreted enamel proteins could attach to individual enamel mineral ribbons and mold their cross-sectional dimensions as they simultaneously elongate and orient them in the direction of the retrograde movement of the ameloblast membrane.<br /> (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1095-8657
Volume :
213
Issue :
4
Database :
MEDLINE
Journal :
Journal of structural biology
Publication Type :
Academic Journal
Accession number :
34715329
Full Text :
https://doi.org/10.1016/j.jsb.2021.107805