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A site assessment tool for inpatient controlled human infection models for enteric disease pathogens.
- Source :
-
Clinical trials (London, England) [Clin Trials] 2022 Feb; Vol. 19 (1), pp. 116-118. Date of Electronic Publication: 2021 Oct 28. - Publication Year :
- 2022
-
Abstract
- The use of the controlled human infection model to facilitate product development and to advance understanding of host-pathogen interactions is of increasing interest. While administering a virulent (or infective) organism to a susceptible host necessitates an ongoing evaluation of safety and ethical considerations, a central theme in conducting these studies in a safe and ethical manner that yields actionable data is their conduct in facilities well-suited to address their unique attributes. To that end, we have developed a framework for evaluating potential sites in which to conduct inpatient enteric controlled human infection model to ensure consistency and increase the likelihood of success.
- Subjects :
- Humans
Host-Pathogen Interactions
Inpatients
Subjects
Details
- Language :
- English
- ISSN :
- 1740-7753
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical trials (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34708664
- Full Text :
- https://doi.org/10.1177/17407745211052473