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Novel Ratio Soluble Fms-like Tyrosine Kinase-1/Angiotensin-II (sFlt-1/ANG-II) in Pregnant Women Is Associated with Critical Illness in COVID-19.
- Source :
-
Viruses [Viruses] 2021 Sep 23; Vol. 13 (10). Date of Electronic Publication: 2021 Sep 23. - Publication Year :
- 2021
-
Abstract
- Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an essential role in the pathogenesis of COVID-19, we hypothesized that angiogenic marker (sFlt-1) and RAS components (ANG-II and ACE-2) may be related to adverse outcomes in pregnant women with COVID-19; Methods: Prospective cohort study. Primary outcome was severe pneumonia. Secondary outcomes were ICU admission, intubation, sepsis, and death. Spearman's Rho test was used to analyze the correlation between sFlt-1 and ANG-II levels. The sFlt-1/ANG-II ratio was determined and the association with each adverse outcome was explored by logistic regression analysis and the prediction was assessed using receiver-operating-curve (ROC); Results: Among 80 pregnant women with COVID-19, the sFlt-1/ANG-II ratio was associated with an increased probability of severe pneumonia (odds ratio [OR]: 1.31; p = 0.003), ICU admission (OR: 1.05; p = 0.007); intubation (OR: 1.09; p = 0.008); sepsis (OR: 1.04; p = 0.008); and death (OR: 1.04; p = 0.018); Conclusion: sFlt-1/ANG-II ratio is a good predictor of adverse events such as pneumonia, ICU admission, intubation, sepsis, and death in pregnant women with COVID-19.
- Subjects :
- Adult
Angiotensin II analysis
Angiotensin II physiology
Biomarkers
COVID-19 complications
Cohort Studies
Critical Illness
Female
Humans
Mexico epidemiology
Placenta metabolism
Pre-Eclampsia
Pregnancy
Pregnant Women
Prospective Studies
SARS-CoV-2 metabolism
SARS-CoV-2 pathogenicity
Vascular Endothelial Growth Factor Receptor-1 analysis
Vascular Endothelial Growth Factor Receptor-1 physiology
Angiotensin II metabolism
COVID-19 metabolism
Vascular Endothelial Growth Factor Receptor-1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 13
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 34696336
- Full Text :
- https://doi.org/10.3390/v13101906