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Electrochemotherapy for the palliative management of non-skin-origin head and neck cancer: case series and UK national survey.
- Source :
-
The Journal of laryngology and otology [J Laryngol Otol] 2022 Mar; Vol. 136 (3), pp. 256-260. Date of Electronic Publication: 2021 Oct 25. - Publication Year :
- 2022
-
Abstract
- Objectives: Electrochemotherapy uses electric fields to facilitate the influx of chemotherapy into cancer cells, producing a targeted effect. For head and neck cancer, it is mainly used for palliation of non-skin-origin metastases. It is used infrequently in the UK. This paper presents our experience and a UK survey to identify its frequency of use.<br />Methods: Between 2016 and 2019, a prospective database was created and reviewed. Only patients with non-skin-origin metastatic head and neck cancer, with no other palliative options, were included. Survival length, complications and symptomatic benefit were assessed. The survey was conducted via e-mail.<br />Results: Five patients were included: three with squamous cell carcinoma, one with esthesioneuroblastoma and one with hepatocellular carcinoma. Survival ranged from 1 month to over 20 months. Minor complications were seen. Only 15 out of 69 UK head and neck multidisciplinary teams offer electrochemotherapy.<br />Conclusion: Electrochemotherapy is a well-tolerated adjunct to standard palliation of metastatic head and neck cancer, and is offered by a limited number of UK multidisciplinary teams.
- Subjects :
- Adult
Aged
Carcinoma, Hepatocellular secondary
Carcinoma, Squamous Cell secondary
Esthesioneuroblastoma, Olfactory secondary
Head and Neck Neoplasms secondary
Humans
Male
Retrospective Studies
Surveys and Questionnaires
Treatment Outcome
United Kingdom
Carcinoma, Hepatocellular drug therapy
Carcinoma, Squamous Cell drug therapy
Electrochemotherapy
Esthesioneuroblastoma, Olfactory drug therapy
Head and Neck Neoplasms drug therapy
Palliative Care
Subjects
Details
- Language :
- English
- ISSN :
- 1748-5460
- Volume :
- 136
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of laryngology and otology
- Publication Type :
- Academic Journal
- Accession number :
- 34689844
- Full Text :
- https://doi.org/10.1017/S0022215121002942