Chemical Constituents of the Deep-Sea-Derived Penicillium solitum .

A systematic chemical investigation of the deep-sea-derived fungus Penicillium solitum MCCC 3A00215 resulted in the isolation of one novel polyketide ( 1 ), two new alkaloids ( 2 and 3 ), and 22 known ( 4 - 2 5 ) compounds. The structures of the new compounds were established mainly on the basis of exhaustive analysis of 1D and 2D NMR data. Viridicatol ( 13 ) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC ₅₀ values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC ₅₀ value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester ( 9 ) and penicopeptide A ( 10 ) showed moderate effects (IC ₅₀ = 50 and 58 μM, respectively).