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Chemoinformatic analysis of alkaloids isolated from Peganum genus.
- Source :
-
Molecular diversity [Mol Divers] 2022 Aug; Vol. 26 (4), pp. 2257-2267. Date of Electronic Publication: 2021 Oct 21. - Publication Year :
- 2022
-
Abstract
- Peganum genus is rich with its high phytochemical and botanical variability. Peganum species have been used as a sedative, antitumor, analgesic and antidepressant. This paper aims to study the molecular diversity of Peganum genus and to shed more light on the structure-activity relationship of the alkaloids isolated from Peganum genus. All Peganum alkaloids were grouped according to their structural properties. A chemoinformatic approach (SwissTargetPrediction) was used to determine the molecular targets of these alkaloids. To analyze and visualize the results, R software was used to generate hierarchical clustering heatmaps. The results of this study can help researchers to better understand the structure-activity relationship of Peganum alkaloids and how substitution can affect the biological activity of those alkaloids.<br /> (© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Details
- Language :
- English
- ISSN :
- 1573-501X
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular diversity
- Publication Type :
- Academic Journal
- Accession number :
- 34674079
- Full Text :
- https://doi.org/10.1007/s11030-021-10331-2