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Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment.
- Source :
-
International journal of biological sciences [Int J Biol Sci] 2021 Sep 21; Vol. 17 (14), pp. 3981-3992. Date of Electronic Publication: 2021 Sep 21 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Enolase 1 (ENO1) is a moonlighting protein, function as a glycolysis enzyme, a plasminogen receptor and a DNA binding protein. ENO1 play an important role in the process of cancer development. The transcription, translation, post-translational modifying activities and the immunoregulatory role of ENO1 at the cancer development is receiving increasing attention. Some function model studies have shown that ENO1 is a potential target for cancer treatment. In this review, we provide a comprehensive overview of the characterization, function, related transduction cascades of ENO1 and its roles in the pathophysiology of cancers, which is a consequence of ENO1 signaling dysregulation. And the development of novels anticancer agents that targets ENO1 may provide a more attractive option for the treatment of cancers. The data of sarcoma and functional cancer models indicates that ENO1 may become a new potential target for anticancer therapy.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)
- Subjects :
- Antineoplastic Agents therapeutic use
Biomarkers, Tumor chemistry
Biomarkers, Tumor metabolism
DNA-Binding Proteins chemistry
DNA-Binding Proteins metabolism
Humans
Phosphopyruvate Hydratase chemistry
Phosphopyruvate Hydratase metabolism
Protein Processing, Post-Translational
Signal Transduction
Structure-Activity Relationship
Tumor Suppressor Proteins chemistry
Tumor Suppressor Proteins metabolism
Antineoplastic Agents pharmacology
DNA-Binding Proteins drug effects
Neoplasms drug therapy
Phosphopyruvate Hydratase drug effects
Tumor Suppressor Proteins drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1449-2288
- Volume :
- 17
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- International journal of biological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34671213
- Full Text :
- https://doi.org/10.7150/ijbs.63556