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Age Under 30 Years As a Predictor of Poor Survival in a Cohort of Mexican Women With Breast Cancer.
- Source :
-
Cancer control : journal of the Moffitt Cancer Center [Cancer Control] 2021 Jan-Dec; Vol. 28, pp. 10732748211047408. - Publication Year :
- 2021
-
Abstract
- Introduction: Young women under 30 years with breast cancer (BC) are an emerging challenge. The purpose is to identify prognostic factors for survival in young women under 30 years of age with BC.<br />Material and Methods: A retrospective cohort study was conducted among women younger than or equal to 40 years with BC and who were treated at the State Cancer Center during the period 2012-2017. Overall survival was assessed using the Kaplan-Meier method and the log-rank test. Univariate and multivariate analysis assessed survival predictors using Cox proportional hazards regression model.<br />Results: 282 young women were included. The >30-year-old subgroup showed a significant association with excess weight ( P = .002) compared to the <30-year-old group. The <30-year-old subgroup showed a poor overall survival (56.7%), as well as highly significant values in advanced clinical stages, metastatic nodules, metastasis, and neoadjuvant therapy ( P < .001). In Model 3 of the multivariate analysis, age <30 years (HR = 3.0; 95% CI 1.1 to 8.6), triple negative subtype (HR = 2.6; 95% CI 1.1 to 6.0), tumor size >5 cm HR = 2.3; 95% CI 1.03 to 5.1), and advanced clinical stages (HR = 6.6 95% CI 1.3 to 35.5) persisted as predictors.<br />Conclusions: Being very young (<30 years) is a predictor for limited survival compared to the age of 30-40 years, as well as the tumor covariates for a worse prognosis: triple negative subtype, advanced stages, positive lymph nodes, and distant metastases in liver.
- Subjects :
- Adult
Body Weight
Female
Humans
Kaplan-Meier Estimate
Neoadjuvant Therapy methods
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Triple Negative Breast Neoplasms mortality
Triple Negative Breast Neoplasms pathology
Tumor Burden
Breast Neoplasms mortality
Breast Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-2359
- Volume :
- 28
- Database :
- MEDLINE
- Journal :
- Cancer control : journal of the Moffitt Cancer Center
- Publication Type :
- Academic Journal
- Accession number :
- 34670417
- Full Text :
- https://doi.org/10.1177/10732748211047408