Hyperhomocysteinemia Promotes Carotid Artery Damage in Newly Diagnosed Type 2 Diabetic Patients Without Hypercholesterolemia.

Background: The relationship between serum homocysteine levels and carotid artery damage in subjects with newly diagnosed type 2 diabetes mellitus remains unclear. The effect of hyperhomocysteinemia (HHCY) on carotid artery damage in patients with different cholesterol levels needs to be further investigated. Methods: In total 456 newly diagnosed type 2 diabetes from Beijing Chaoyang Hospital were recruited into the study. Patients were divided into four groups according to the levels of serum homocysteine and cholesterol. Carotid artery damage was defined as thickened intima-media and/or plaque formation. Results: In all the subjects, 80.2% patients had HHCY. The incidence of carotid artery injury was significantly lower in diabetic patients with normal homocysteine levels and nonhypercholesterolemia. Spearman correlation analysis showed homocysteine was positively correlated with free fatty acid and negatively correlated with glucose metabolism parameters. Logistic regression showed HHCY was correlated with carotid artery injury after adjusting for traditional cerebrovascular risk factors in type 2 diabetes without hypercholesterolemia (odds risk = 3.197, P  = 0.022). Whereas HHCY was not associated with carotid artery injury in either total study population or hypercholesterolemia subgroup. Conclusions: HHCY was correlated with carotid artery damage in newly diagnosed type 2 diabetic subjects without hypercholesterolemia. How to improve the adverse vascular outcomes mediated by HHCY for diabetic patients needed further investigation.