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Practical management of patients with hematological diseases during the COVID-19 pandemic in Japan.
- Source :
-
International journal of hematology [Int J Hematol] 2021 Dec; Vol. 114 (6), pp. 709-718. Date of Electronic Publication: 2021 Oct 20. - Publication Year :
- 2021
-
Abstract
- Polymerase chain reaction (PCR) tests cannot always detect the SARS-CoV-2 virus, possibly due to differences in sensitivity between sample types. Under these circumstances, immunochromatography may serve as an alternative method to detect anti-SARS-CoV-2 IgG antibodies that indicate a history of infection. In our analysis of patients with severe COVID-19 infection, we found that 14 of 19 serum samples were positive for IgG antibodies, whereas 6 of 10 samples from patients with asymptomatic or mild cases were negative. Two patients with immune thrombocytopenia who were treated with prednisolone experienced aggressive COVID-19-related respiratory failure and eventually died. Patients not in remission and those who received steroid-based chemotherapy had a higher risk of death, and patients with lymphoid malignancies including lymphoma and myeloma died in larger numbers than those with myeloid malignancies. A stricter cohorting strategy based on repeat PCR tests or isolation to a private room should be adopted in routine care in hematology departments to prevent viral spread to the environment.<br /> (© 2021. Japanese Society of Hematology.)
- Subjects :
- Antibodies, Viral blood
Biomarkers blood
Female
Hematologic Diseases complications
Hematologic Diseases mortality
Humans
Immunoassay methods
Immunoglobulin G blood
Infection Control methods
Japan
Male
Patient Isolation
Polymerase Chain Reaction
Risk
SARS-CoV-2 immunology
Severity of Illness Index
Survival Rate
COVID-19 complications
COVID-19 diagnosis
COVID-19 mortality
COVID-19 prevention & control
Cross Infection prevention & control
Hematologic Diseases therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 114
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 34669154
- Full Text :
- https://doi.org/10.1007/s12185-021-03175-x