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Eleven new C 19 -diterpenoid alkaloids from Delphinium elatum cv. Pacific Giant.
- Source :
-
Journal of natural medicines [J Nat Med] 2022 Jan; Vol. 76 (1), pp. 161-170. Date of Electronic Publication: 2021 Oct 20. - Publication Year :
- 2022
-
Abstract
- Diterpenoid alkaloids, the main components of plants of the genera Aconitum, Delphinium, and Garrya, are a group of natural products with notable chemical properties and biological activities. Several C <subscript>19</subscript> -diterpenoid alkaloid components from Delphinium elatum cv. Pacific Giant, as well as their derivatives, exhibited cytotoxic activity against lung, prostate, cervical, and vincristine-resistant cervical cancer cell lines. In the current phytochemical investigation on the seeds of D. elatum cv. Pacific Giant, eleven new C <subscript>19</subscript> -diterpenoid alkaloids, elapaciline (1), meladine (2), melapacitine (3), iminoeladine (4), 19-oxopaciline (5), 19-oxopacinine (6), N-deethyldelpheline (7), N-deethylpacinine (8), N-deethyl-19-oxoeladine (9), N-deethyl-N-formyleladine (10), and N-deethyl-N-formyldelpheline (11), together with 15 known C <subscript>19</subscript> -diterpenoid alkaloids were isolated. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Three known diterpenoid alkaloids, 6-dehydrodelcorine (12), delelatine (23), and 6-dehydroeldelidine (24), were isolated for the first time from this plant. Six of the new C <subscript>19</subscript> -diterpenoid alkaloids (2, 4-7, and 11) and three of the known diterpenoid alkaloids (18, 23, and 24) were evaluated for cytotoxic activity against five human tumor cell lines.<br /> (© 2021. The Japanese Society of Pharmacognosy.)
Details
- Language :
- English
- ISSN :
- 1861-0293
- Volume :
- 76
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of natural medicines
- Publication Type :
- Academic Journal
- Accession number :
- 34669108
- Full Text :
- https://doi.org/10.1007/s11418-021-01569-z