Back to Search
Start Over
An electrically coupled pioneer circuit enables motor development via proprioceptive feedback in Drosophila embryos.
- Source :
-
Current biology : CB [Curr Biol] 2021 Dec 06; Vol. 31 (23), pp. 5327-5340.e5. Date of Electronic Publication: 2021 Oct 18. - Publication Year :
- 2021
-
Abstract
- Precocious movements are widely seen in embryos of various animal species. Whether such movements via proprioceptive feedback play instructive roles in motor development or are a mere reflection of activities in immature motor circuits is a long-standing question. Here we image the emerging motor activities in Drosophila embryos that lack proprioceptive feedback and show that proprioceptive experience is essential for the development of locomotor central pattern generators (CPGs). Downstream of proprioceptive inputs, we identify a pioneer premotor circuit composed of two pairs of segmental interneurons, whose gap-junctional transmission requires proprioceptive experience and plays a crucial role in CPG formation. The circuit autonomously generates rhythmic plateau potentials via IP <subscript>3</subscript> -mediated Ca <superscript>2+</superscript> release from internal stores, which contribute to muscle contractions and hence produce proprioceptive feedback. Our findings demonstrate the importance of self-generated movements in instructing motor development and identify the cells, circuit, and physiology at the core of this proprioceptive feedback.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Gap Junctions
Interneurons
Movement physiology
Drosophila
Feedback, Sensory
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0445
- Volume :
- 31
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Current biology : CB
- Publication Type :
- Academic Journal
- Accession number :
- 34666002
- Full Text :
- https://doi.org/10.1016/j.cub.2021.10.005