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Mapping vitamin B 6 metabolism by hydrazoCEST magnetic resonance imaging.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Oct 19; Vol. 57 (83), pp. 10867-10870. Date of Electronic Publication: 2021 Oct 19. - Publication Year :
- 2021
-
Abstract
- A new CEST-MRI contrast agent, 2-HYNIC, capable of sensing aromatic aldehydes is reported. Pyridoxal 5'-phosphate, a key Vitamin B <subscript>6</subscript> metabolite necessary for >140 biotransformations was mapped by CEST-MRI in vitro and in vivo in lung cancer. 2-HYNIC provided access to this key biomarker associated with a variety of human diseases.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 83
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 34665184
- Full Text :
- https://doi.org/10.1039/d1cc03704h