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Distinguishing between the complications of Wilson disease-related cirrhosis and HBV-related cirrhosis.
- Source :
-
Current medical research and opinion [Curr Med Res Opin] 2022 Jan; Vol. 38 (1), pp. 75-81. Date of Electronic Publication: 2021 Oct 24. - Publication Year :
- 2022
-
Abstract
- Objective: Complications affect the outcome of patients with cirrhosis. The favorable prognosis of patients with Wilson disease (WD)-related cirrhosis suggests that its complications differ from those of hepatitis B virus (HBV) infection-related cirrhosis. We aimed to delineate the differences in complications between WD-related and HBV-related cirrhosis.<br />Methods: The electronic-medical data from patients with WD-related and HBV-related cirrhosis were extracted and analyzed.<br />Results: In total, 211 patients with WD-related cirrhosis and 374 patients with HBV-related cirrhosis were enrolled. Most patients with WD progressed to cirrhosis <10 years after disease onset, whereas those with HBV infection often progressed after >10 years. Patients with WD-related cirrhosis had a markedly lower prevalence of ascites (8.5% vs . 38.5%), gastroesophageal varices/variceal bleeding (13.3% vs . 47.6%), renal impairment (0 vs . 7.6%) and primary liver cancer (0 vs . 39.3%; all p < .001) than those with HBV-related cirrhosis. After adjustment for potential confounders, patients with WD-related cirrhosis carried a lower risk of varices/variceal bleeding.<br />Conclusions: Although patients with WD progressed to cirrhosis much faster, the prevalence of complications from WD-related cirrhosis was low. Patients with WD-related cirrhosis were less likely to develop gastroesophageal varices/variceal bleeding than those with HBV-related cirrhosis.
- Subjects :
- Gastrointestinal Hemorrhage
Hepatitis B virus
Humans
Liver Cirrhosis epidemiology
Liver Cirrhosis etiology
Esophageal and Gastric Varices epidemiology
Esophageal and Gastric Varices etiology
Hepatolenticular Degeneration complications
Hepatolenticular Degeneration diagnosis
Hepatolenticular Degeneration epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-4877
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current medical research and opinion
- Publication Type :
- Academic Journal
- Accession number :
- 34665066
- Full Text :
- https://doi.org/10.1080/03007995.2021.1993160