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CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study.
- Source :
-
Molecular medicine (Cambridge, Mass.) [Mol Med] 2021 Oct 18; Vol. 27 (1), pp. 129. Date of Electronic Publication: 2021 Oct 18. - Publication Year :
- 2021
-
Abstract
- Background: Host inflammation contributes to determine whether SARS-CoV-2 infection causes mild or life-threatening disease. Tools are needed for early risk assessment.<br />Methods: We studied in 111 COVID-19 patients prospectively followed at a single reference Hospital fifty-three potential biomarkers including alarmins, cytokines, adipocytokines and growth factors, humoral innate immune and neuroendocrine molecules and regulators of iron metabolism. Biomarkers at hospital admission together with age, degree of hypoxia, neutrophil to lymphocyte ratio (NLR), lactate dehydrogenase (LDH), C-reactive protein (CRP) and creatinine were analysed within a data-driven approach to classify patients with respect to survival and ICU outcomes. Classification and regression tree (CART) models were used to identify prognostic biomarkers.<br />Results: Among the fifty-three potential biomarkers, the classification tree analysis selected CXCL10 at hospital admission, in combination with NLR and time from onset, as the best predictor of ICU transfer (AUC [95% CI] = 0.8374 [0.6233-0.8435]), while it was selected alone to predict death (AUC [95% CI] = 0.7334 [0.7547-0.9201]). CXCL10 concentration abated in COVID-19 survivors after healing and discharge from the hospital.<br />Conclusions: CXCL10 results from a data-driven analysis, that accounts for presence of confounding factors, as the most robust predictive biomarker of patient outcome in COVID-19.<br /> (© 2021. The Author(s).)
- Subjects :
- Biomarkers blood
C-Reactive Protein metabolism
COVID-19 blood
COVID-19 immunology
COVID-19 mortality
Comorbidity
Coronary Artery Disease blood
Coronary Artery Disease immunology
Coronary Artery Disease mortality
Creatine blood
Diabetes Mellitus blood
Diabetes Mellitus immunology
Diabetes Mellitus mortality
Female
Hospitalization
Humans
Hypertension blood
Hypertension immunology
Hypertension mortality
Immunity, Humoral
Immunity, Innate
Inflammation
Intensive Care Units
L-Lactate Dehydrogenase blood
Leukocyte Count
Lymphocytes immunology
Lymphocytes pathology
Male
Middle Aged
Neutrophils immunology
Neutrophils pathology
Prognosis
Prospective Studies
Retrospective Studies
SARS-CoV-2
Severity of Illness Index
Survival Analysis
COVID-19 diagnosis
Chemokine CXCL10 blood
Coronary Artery Disease diagnosis
Diabetes Mellitus diagnosis
Hypertension diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1528-3658
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular medicine (Cambridge, Mass.)
- Publication Type :
- Academic Journal
- Accession number :
- 34663207
- Full Text :
- https://doi.org/10.1186/s10020-021-00390-4