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Challenges in Optimizing Lipid Management in Women.
- Source :
-
Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2022 Dec; Vol. 36 (6), pp. 1197-1220. Date of Electronic Publication: 2021 Oct 18. - Publication Year :
- 2022
-
Abstract
- While there are physiologic differences in lipid metabolism in men and women, pharmacologic therapy is very effective in both with similar management strategies recommended in the current guidelines for the management of dyslipidemia. Despite similar guidelines for treatment, studies have shown that women have worse control of dyslipidemia than their male counterparts. This may stem from multiple contributing factors including underestimation of cardiovascular disease risk in women, decreased prescription and utilization of lipid-lowering therapies, decreased medication adherence, and higher risk of statin intolerance, all of which may contribute to lower attainment of lipid targets. Furthermore, heart disease is the leading cause of mortality in women, with heart disease noted an average of 7-10 years later than in men. This has historically led to the misperception that women are protected from heart disease and can be treated less aggressively. In fact, traditional risk factors for atherosclerotic cardiovascular disease often impact risk in women to a greater extent than they do in men. Unique risk factors such as pregnancy-related disorders also contribute to the level of risk and therefore warrant consideration in risk stratification. This review summarizes the efficacy of contemporary lipid-lowering therapies in women versus men and discusses the challenges that arise with lipid management in women along with potential ways to tackle these obstacles.<br /> (© 2021. Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Male
Female
Risk Factors
Lipids therapeutic use
Cardiovascular Diseases diagnosis
Cardiovascular Diseases drug therapy
Cardiovascular Diseases prevention & control
Dyslipidemias diagnosis
Dyslipidemias drug therapy
Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects
Heart Diseases drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7241
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cardiovascular drugs and therapy
- Publication Type :
- Academic Journal
- Accession number :
- 34661802
- Full Text :
- https://doi.org/10.1007/s10557-021-07273-0