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Acute lymphoblastic leukaemia under 2 years.
- Source :
-
Archives of disease in childhood [Arch Dis Child] 1986 Oct; Vol. 61 (10), pp. 1007-12. - Publication Year :
- 1986
-
Abstract
- Presenting features and natural history were assessed in 48 children with acute lymphoblastic leukaemia less than 2 years of age at diagnosis. Of these, 16 were less than 1 year (group 1) and 32 were between 1 and 2 years (group 2). Results were compared with a group of 348 children between the ages of 2 and 14 years (group 3) diagnosed over the same period. The children in group 1 presented with a higher prevalence of null cell acute lymphoblastic leukaemia, leucocyte counts greater than 100 X 10(9)/l, and hepatosplenomegaly and had a higher central nervous system (CNS) relapse rate and shorter duration of remission than those in the other two groups. Disease free survival and overall survival in group 2 paralleled that of group 3, although children in group 2 had a significantly higher CNS relapse rate. Neurological toxicity resulting from treatment with methotrexate and radiation was common in those under 2 years as a whole. In conclusion, children under 1 year have a particularly poor prognosis, while those between 1 and 2 years have a prognosis similar to that in the older age group. Alternative approaches to CNS prophylaxis are needed to reduce the high prevalence of CNS disease and toxicity.
- Subjects :
- Adolescent
Age Factors
Child
Child, Preschool
England
Female
Humans
Infant
Infant, Newborn
Leukemia, Lymphoid complications
Leukemia, Lymphoid drug therapy
Leukocyte Count
Male
Methotrexate adverse effects
Nervous System Diseases etiology
Prognosis
Radiotherapy adverse effects
Leukemia, Lymphoid mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2044
- Volume :
- 61
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archives of disease in childhood
- Publication Type :
- Academic Journal
- Accession number :
- 3465275
- Full Text :
- https://doi.org/10.1136/adc.61.10.1007