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Anti-gastric cancer activity of cultivated Dendrobium huoshanense stem polysaccharide in tumor-bearing mice: Effects of molecular weight and O-acetyl group.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2021 Dec 01; Vol. 192, pp. 590-599. Date of Electronic Publication: 2021 Oct 11. - Publication Year :
- 2021
-
Abstract
- The present study aimed at assuring whether homogeneous cultivated Dendrobium huoshanense stem polysaccharide (cDHPS) could inhibit gastric cancer in vivo, and whether its anti-gastric cancer activity could be affected by its molecular weight and O-acetyl group. Three different fractions (cDHPS-I, cDHPS-II and cDHPS-III) with decreased molecular weights and one fraction (cDHPS-IV) without O-acetyl group were prepared from cDHPS. Their structures were identified systematically. The backbone of cDHPS-I-III was the same as that of cDHPS, while their relative molecular weights displayed a decreasing order as follows: cDHPS > cDHPS-I > cDHPS-II > cDHPS-III. The backbone of cDHPS-IV was similar to those of cDHPS and cDHPS-I-III, but with the absence of O-acetyl groups. Animal experiments exhibited that cDHPS and cDHPS-I-IV could significantly inhibit tumor growth, induce tumor cell apoptosis, suppress tumor angiogenesis and enhance T cell immune response of murine forestomach carcinoma (MFC) tumor-bearing mice. Moreover, all the above effects of cDHPS and cDHPS-I-IV on MFC tumor-bearing mice exhibited a decreasing order as follows: cDHPS > cDHPS-I > cDHPS-II > cDHPS-III > cDHPS-IV. The results suggest that cDHPS could inhibit gastric cancer in vivo, and its anti-gastric cancer activity was closely linked with its molecular weight and O-acetyl group.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Angiogenesis Inhibitors chemistry
Angiogenesis Inhibitors pharmacology
Animals
Antineoplastic Agents, Phytogenic chemistry
Apoptosis drug effects
Cell Line, Tumor
Disease Models, Animal
Humans
Immunologic Factors chemistry
Immunologic Factors pharmacology
Magnetic Resonance Spectroscopy
Male
Mice
Molecular Structure
Molecular Weight
Plant Extracts chemistry
Polysaccharides chemistry
T-Lymphocytes drug effects
T-Lymphocytes immunology
T-Lymphocytes metabolism
Xenograft Model Antitumor Assays
Antineoplastic Agents, Phytogenic pharmacology
Dendrobium chemistry
Plant Extracts pharmacology
Plant Stems chemistry
Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 192
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 34648801
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2021.10.016