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Autophagy deficiency boosts the production of kojic acid in the filamentous fungus Aspergillus oryzae.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2021 Nov 24; Vol. 85 (12), pp. 2429-2433. - Publication Year :
- 2021
-
Abstract
- We found that the expression of genes involved in kojic acid (KA) biosynthesis, kojA, kojR, and kojT, was highly elevated in the Aspergillus oryzae autophagy-deficient mutants. In agreement, KA production was much increased in these mutants. Nuclear translocation of KojR, a transcription factor, was observed in the autophagy mutants before they were starved, explaining why KA production was boosted.<br /> (© The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)
Details
- Language :
- English
- ISSN :
- 1347-6947
- Volume :
- 85
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34643660
- Full Text :
- https://doi.org/10.1093/bbb/zbab175