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Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer.
- Source :
-
The EMBO journal [EMBO J] 2021 Nov 15; Vol. 40 (22), pp. e109683. Date of Electronic Publication: 2021 Oct 12. - Publication Year :
- 2021
-
Abstract
- While canonical and non-canonical functions of pyruvate kinase M2 (PKM2) are recognized to mediate often-opposing roles in cancer, its contribution to cellular and systemic fatty acid homeostasis remains poorly understood. A new study by Liu et al (2021) uncovers ER transmembrane protein TMEM33 as a novel target of PKM2, which is essential for regulation of cancer cell cholesterol metabolism. These findings highlight the diversity of tissue-specific functions of PKM2 and potential implications for cancer treatment.<br /> (© 2021 The Authors.)
Details
- Language :
- English
- ISSN :
- 1460-2075
- Volume :
- 40
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- The EMBO journal
- Publication Type :
- Academic Journal
- Accession number :
- 34642948
- Full Text :
- https://doi.org/10.15252/embj.2021109683