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Butyrylated starch protects mice from DSS-induced colitis: combined effects of butyrate release and prebiotic supply.
- Source :
-
Food & function [Food Funct] 2021 Nov 15; Vol. 12 (22), pp. 11290-11302. Date of Electronic Publication: 2021 Nov 15. - Publication Year :
- 2021
-
Abstract
- Butyrate has recently emerged as a promising substance for the therapy of colitis. To overcome the shortcomings implicated in the existing delivery systems of butyrate, we utilized butyrylated starch to specifically deliver butyrate to the colon. Herein, we describe the stable loading of butyrate via chemical bonds with a heterogeneous distribution throughout the particle. Butyrylated starch supply increased butyrate as well as total short-chain fatty acid contents at the end of the intervention period. Moreover, butyrylated starch showed multiple effects on the suppression of DSS-induced colitis. From the observation of the gut-liver axis, reduced hepatic inflammation and hepatocyte damage further confirmed alleviated colonic inflammation. Given that butyrylated starch has the combined effects of specific release of butyrate in the colon and extra supply of fermentable substrates for gut microbiota, this work provides an effective strategy for the assistant therapy of colitis.
- Subjects :
- Animals
Colitis chemically induced
Dextran Sulfate adverse effects
Intestinal Mucosa drug effects
Intestinal Mucosa metabolism
Male
Mice
Mice, Inbred C57BL
Protective Agents pharmacology
Butyrates chemistry
Butyrates pharmacokinetics
Butyrates pharmacology
Colitis metabolism
Prebiotics
Starch chemistry
Starch pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 12
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 34635904
- Full Text :
- https://doi.org/10.1039/d1fo01913a