Back to Search Start Over

V Spanish Consensus Conference on Helicobacter pylori infection treatment.

Authors :
Gisbert JP
Alcedo J
Amador J
Bujanda L
Calvet X
Castro-Fernández M
Fernández-Salazar L
Gené E
Lanas Á
Lucendo AJ
Molina-Infante J
Nyssen OP
Pérez-Aisa A
Puig I
Source :
Gastroenterologia y hepatologia [Gastroenterol Hepatol] 2022 May; Vol. 45 (5), pp. 392-417. Date of Electronic Publication: 2021 Oct 07.
Publication Year :
2022

Abstract

Helicobacter pylori infection is very common in the Spanish population and represents the main cause of chronic gastritis, peptic ulcer, and gastric cancer. The last iteration of Spanish consensus guidelines on H. pylori infection was conducted in 2016. Recent changes in therapeutic schemes along with increasing supporting evidence were key for developing the V Spanish Consensus Conference (May 2021). Fourteen experts performed a systematic review of the scientific evidence and developed a series of recommendations that were subjected to an anonymous Delphi process of iterative voting. Scientific evidence and the strength of the recommendation were classified using GRADE guidelines. An eradication therapy, when prescribed empirically, is considered acceptable when it reliably achieves, or preferably surpass, 90% cure rates. Currently, only quadruple therapies (with or without bismuth) and generally lasting 14 days, accomplish this goal in first- and second-line therapies. A non-bismuth quadruple concomitant regimen (proton pump inhibitor, clarithromycin, amoxicillin, and metronidazole) or a quadruple bismuth-based combination (proton pump inhibitor, bismuth, tetracycline, and metronidazole), are recommended as first-line regimens. Rescue therapies after eradication failure and management of H. pylori infection in peptic ulcer disease were also reviewed.<br /> (Copyright © 2021 Elsevier España, S.L.U. All rights reserved.)

Details

Language :
English; Spanish; Castilian
ISSN :
0210-5705
Volume :
45
Issue :
5
Database :
MEDLINE
Journal :
Gastroenterologia y hepatologia
Publication Type :
Academic Journal
Accession number :
34629204
Full Text :
https://doi.org/10.1016/j.gastrohep.2021.07.011