Heart failure in diabetes.

Authors :: Jankauskas SS
Kansakar U
Varzideh F
Wilson S
Mone P
Lombardi A
Gambardella J
Santulli G
Source :: Metabolism: clinical and experimental [Metabolism] 2021 Dec; Vol. 125, pp. 154910. Date of Electronic Publication: 2021 Oct 08.
Publication Year :: 2021
Abstract: Heart failure and cardiovascular disorders represent the leading cause of death in diabetic patients. Here we present a systematic review of the main mechanisms underlying the development of diabetic cardiomyopathy. We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.<br />Competing Interests: Declaration of competing interest Nothing to declare.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)