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Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment.
- Source :
-
Journal of nanobiotechnology [J Nanobiotechnology] 2021 Oct 09; Vol. 19 (1), pp. 308. Date of Electronic Publication: 2021 Oct 09. - Publication Year :
- 2021
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Abstract
- In Asia, including Taiwan, malignant tumors such as Hepatocellular carcinoma (HCC) one of the liver cancer is the most diagnosed subtype. Magnetic resonance imaging (MRI) has been a typical diagnostic method for accurately diagnosing HCC. When it is difficult to demonstrate non-enhanced MRI of tumors, radiologists can use contrast agents (such as Gd <superscript>3+</superscript> , Fe <subscript>3</subscript> O <subscript>4</subscript> , or FePt) for T1-weighted and T2-weighted imaging remain in the liver for a long time to facilitate diagnosis via MRI. However, it is sometimes difficult for T2-weighted imaging to detect small tumor lesions because the liver tissue may absorb iron ions. This makes early cancer detection a challenging goal. This challenge has prompted current research to create novel nanocomposites for enhancing the noise-to-signal ratio of MRI. To develop a method that can more efficiently diagnose and simultaneously treat HCC during MRI examination, we designed a functionalized montmorillonite (MMT) material with a porous structure to benefit related drugs, such as mitoxantrone (MIT) delivery or as a carrier for the FePt nanoparticles (FePt NPs) to introduce cancer therapy. Multifunctional FePt@MMT can simultaneously visualize HCC by enhancing MRI signals, treating various diseases, and being used as an inducer of magnetic fluid hyperthermia (MFH). After loading the drug MIT, FePt@MMT-MIT provides both MFH treatment and chemotherapy in one nanosystem. These results ultimately prove that functionalized FePt@MMT-MIT could be integrated as a versatile drugs delivery system by combining with MRI, chemotheraeutic drugs, and magnetic guide targeting.<br /> (© 2021. The Author(s).)
- Subjects :
- Animals
Bentonite chemistry
Cell Line, Tumor
Contrast Media chemistry
Contrast Media toxicity
Humans
Male
Mice
Platinum chemistry
Theranostic Nanomedicine
Carcinoma, Hepatocellular diagnostic imaging
Carcinoma, Hepatocellular metabolism
Drug Carriers chemistry
Drug Carriers toxicity
Liver Neoplasms diagnostic imaging
Liver Neoplasms metabolism
Magnetic Resonance Imaging
Magnetite Nanoparticles chemistry
Magnetite Nanoparticles toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1477-3155
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of nanobiotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 34627267
- Full Text :
- https://doi.org/10.1186/s12951-021-01052-7