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Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic.
- Source :
-
Healthcare (Amsterdam, Netherlands) [Healthc (Amst)] 2021 Dec; Vol. 9 (4), pp. 100581. Date of Electronic Publication: 2021 Sep 09. - Publication Year :
- 2021
-
Abstract
- The interleukin-6 receptor antagonist tocilizumab became widely used early in the coronavirus disease 2019 (COVID-19) pandemic based on small observational studies that suggested clinical benefit in COVID-19 patients with a hyperinflammatory state. To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center. We report their early clinical outcomes and describe the process by which we assembled a team of diverse trainees and stakeholders to extract, analyze, and disseminate data during a time of clinical uncertainty.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 2213-0772
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Healthcare (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 34626958
- Full Text :
- https://doi.org/10.1016/j.hjdsi.2021.100581