Modulation of membrane-cytoskeleton interactions: ezrin as key player.

Authors :: Yin LM
Schnoor M
Source :: Trends in cell biology [Trends Cell Biol] 2022 Feb; Vol. 32 (2), pp. 94-97. Date of Electronic Publication: 2021 Oct 06.
Publication Year :: 2022
Abstract: Membrane-cytoskeleton interactions (MCIs) are mediated by actin-binding proteins (ABPs). Ezrin is a crucial ABP that links membranes to actin filaments during lamellipodia formation, cell polarization, and migration. We discuss the concept of MCI and the potential of ezrin as a druggable target for treating inflammatory diseases and cancers.<br />Competing Interests: Declaration of interests The authors declare no conflicts of interest.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)