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High-density lipoprotein cholesterol: A marker of COVID-19 infection severity?
- Source :
-
Atherosclerosis plus [Atheroscler Plus] 2021 Oct; Vol. 44, pp. 1-9. Date of Electronic Publication: 2021 Aug 24. - Publication Year :
- 2021
-
Abstract
- Background and Aims: To systematically address all the relevant evidence of the association between high-density lipoprotein cholesterol (HDL-C) and COVID-19 infection.<br />Methods: We searched PubMed, PubMed Central and medRxiv databases (up to May 2021) for studies related to HDL-C and COVID-19 infection. A qualitative synthesis of published prospective and retrospective studies for the role of low HDL-C levels on COVID-19 infection severity was performed.<br />Results: Thirty-three studies (6 prospective, 27 retrospective) including 11,918 COVID-19 patients were eligible for the systematic review. Twelve studies compared HDL-C levels on admission in COVID-19 patients with healthy controls. In these 12 studies, COVID-19 patients had significantly lower HDL-C levels on admission compared with that of healthy controls. Twenty-eight studies observed the HDL-C levels among COVID-19 diagnosed patients, to establish the role of low HDL-C values in the prognosis of the infection. Twenty-four studies showed a correlation between low HDL-C levels with disease severity, while only 4 studies showed no association.<br />Conclusions: Low HDL-C levels should be added in the list of the others well-known risk factors for COVID-19 severity.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2021 The Authors.)
Details
- Language :
- English
- ISSN :
- 2667-0895
- Volume :
- 44
- Database :
- MEDLINE
- Journal :
- Atherosclerosis plus
- Publication Type :
- Academic Journal
- Accession number :
- 34622242
- Full Text :
- https://doi.org/10.1016/j.athplu.2021.08.007