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Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Sep 20; Vol. 12, pp. 742631. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- SARS-CoV-2 infection causes COVID-19, ranging from mild to critical disease in symptomatic subjects. It is essential to better understand the immunologic responses occurring in patients with the most severe outcomes. In this study, parameters related to the humoral immune response elicited against SARS-CoV-2 were analysed in 61 patients with different presentations of COVID-19 who were recruited in Hospitals and Primary Healthcare Centres in Madrid, Spain, during the first pandemic peak between April and June 2020. Subjects were allocated as mild patients without hospitalization, severe patients hospitalized or critical patients requiring ICU assistance. Critical patients showed significantly enhanced levels of B cells with memory and plasmablast phenotypes, as well as higher levels of antibodies against SARS-CoV-2 with neutralization ability, which were particularly increased in male gender. Despite all this, antibody-dependent cell-mediated cytotoxicity was defective in these individuals. Besides, patients with critical COVID-19 also showed increased IgG levels against herpesvirus such as CMV, EBV, HSV-1 and VZV, as well as detectable CMV and EBV viremia in plasma. Altogether, these results suggest an enhanced but ineffectual immune response in patients with critical COVID-19 that allowed latent herpesvirus reactivation. These findings should be considered during the clinical management of these patients due to the potential contribution to the most severe disease during SARS-CoV-2 infection.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Vigón, García-Pérez, Rodríguez-Mora, Torres, Mateos, Castillo de la Osa, Cervero, Malo De Molina, Navarro, Murciano-Antón, García-Gutiérrez, Planelles, Alcamí, Pérez-Olmeda, Coiras and López-Huertas.)
- Subjects :
- Aged
Aged, 80 and over
Antibodies, Viral blood
COVID-19 virology
Cohort Studies
Cross-Sectional Studies
Female
Hospitalization
Humans
Intensive Care Units statistics & numerical data
Male
Middle Aged
SARS-CoV-2 genetics
SARS-CoV-2 immunology
Spain
Antibody-Dependent Cell Cytotoxicity
COVID-19 immunology
SARS-CoV-2 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34616404
- Full Text :
- https://doi.org/10.3389/fimmu.2021.742631