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Lipoprotein(a) and subclinical coronary atherosclerosis in asymptomatic individuals.
- Source :
-
Atherosclerosis [Atherosclerosis] 2022 May; Vol. 349, pp. 190-195. Date of Electronic Publication: 2021 Sep 28. - Publication Year :
- 2022
-
Abstract
- Background and Aims: There are limited data regarding the association between lipoprotein(a) (Lp[a]) and subclinical coronary atherosclerosis. This study investigated the association between Lp(a) and subclinical coronary atherosclerosis detected by coronary computed tomographic angiography (CCTA) in an asymptomatic population.<br />Methods: We retrospectively analyzed 7201 asymptomatic individuals (mean age 54.4 ± 7.9 years; 65.3% men with no prior history of coronary artery disease who voluntarily underwent CCTA as part of a general health examination). The degree and extent of subclinical coronary atherosclerosis were evaluated by CCTA. Study participants were stratified into quartiles according to their Lp(a) levels (<4.3, 4.3-8.9, 9.0-20.1, and ≥20.2 mg/dL).<br />Results: Of the study participants, any coronary plaque on CCTA was observed in 2557 (35.5%). Specifically, calcified, non-calcified, and mixed plaques were observed in 2411 (33.5%), 363 (5.0%) and 249 (3.5%) participants, respectively. After adjustment for the presence of cardiovascular risk factors, the fourth Lp(a) quartile was significantly associated with any coronary (odds ratio [OR] 1.212; 95% confidence interval [CI] 1.038-1.416), calcified (1.205, 95% CI 1.030-1.410), non-calcified (1.588, 95% CI 1.152-2.189), or mixed (1.674, 95% CI 1.172-2.391) plaque compared with the first Lp(a) quartile. In addition, 442 (6.1%) had significant coronary artery stenosis (≥50% diameter stenosis). The odds ratio for significant stenosis (1.537, 95% CI 1.153-2.048) was higher in the fourth quartile compared with the first quartile.<br />Conclusions: In this large cross-sectional study with asymptomatic individuals undergoing CCTA, higher Lp(a) level was associated with subclinical coronary atherosclerosis.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Asymptomatic Diseases
Constriction, Pathologic
Coronary Angiography methods
Cross-Sectional Studies
Female
Humans
Lipoprotein(a)
Male
Middle Aged
Retrospective Studies
Risk Factors
Coronary Artery Disease complications
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease epidemiology
Plaque, Atherosclerotic complications
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 349
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 34607706
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2021.09.027