Back to Search
Start Over
BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly: the SCIENCe project.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2021 Dec; Vol. 108, pp. 146-154. Date of Electronic Publication: 2021 Sep 04. - Publication Year :
- 2021
-
Abstract
- Brain-derived neurotrophic factor (BNDF) plays a role in synapse integrity. We investigated in 398 cognitively normal adults (60±8years, 41% female, MMSE=28±1) the joint association of the Val66Met polymorphism of the BDNF gene (Met+/-) and plasma BDNF levels and abnormal cerebrospinal fluid (CSF) amyloid-beta status (A+/-) with cognitive decline and dementia risk. Age-, sex- and education-adjusted linear mixed models showed that compared to Met-A-, Met+A+ showed steeper decline on tests of global cognition, memory, language, attention and executive functioning, while Met-A+ showed steeper decline on a smaller number of tests. There were no associations between Met+A- and cognitive decline. Cox models showed that compared to Met-A-, Met+A+ participants were at increased risk of dementia (HR=8.8, 95%CI: 2.8-27.9), as were Met-A+ participants (HR=6.5, 95%CI: 2.2-19.5). Lower plasma BDNF was associated with an increased risk of progression to dementia in the A+ participants. Our results imply that Met-carriage on top of amyloid-beta pathology might increase rate of cognitive decline to dementia.<br /> (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Aging psychology
Alzheimer Disease genetics
Alzheimer Disease metabolism
Brain-Derived Neurotrophic Factor blood
Brain-Derived Neurotrophic Factor physiology
Dementia genetics
Dementia metabolism
Female
Humans
Male
Middle Aged
Risk
Aging genetics
Aging metabolism
Amyloid beta-Peptides cerebrospinal fluid
Brain-Derived Neurotrophic Factor genetics
Cognition
Cognitive Dysfunction genetics
Cognitive Dysfunction metabolism
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 108
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 34601245
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2021.08.018