High purity 47 Sc production using high-energy photons and natural vanadium targets.

Authors :: Snow MS
Foley A
Ward JL
Kinlaw MT
Stoner J
Carney KP
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2021 Dec; Vol. 178, pp. 109934. Date of Electronic Publication: 2021 Sep 04.
Publication Year :: 2021
Abstract: Scandium-47 ( <superscript>47</superscript> Sc) is of high value for targeted radiotherapy and theranostics; we report a novel, cost-effective approach to produce high-purity <superscript>47</superscript> Sc via photonuclear reactions with natural vanadium. Irradiation at 20 MeV photon end-point energy produces >99.998% pure <superscript>47</superscript> Sc, while irradiation at 38 MeV produces 98.8 ± 1.6% pure <superscript>47</superscript> Sc. Experimental data suggest producing greater than 100 mCi (3700 MBq) of <superscript>47</superscript> Sc using this approach may be feasible. Future research into refinement and scale-up to support pre-clinical research is recommended.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1872-9800
Volume :: 178
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 34598038
Full Text :: https://doi.org/10.1016/j.apradiso.2021.109934

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