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Effect of gene polymorphism on bleeding complications in Chinese Han patients taking warfarin.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2022 Feb; Vol. 78 (2), pp. 205-214. Date of Electronic Publication: 2021 Oct 01. - Publication Year :
- 2022
-
Abstract
- Purpose: The purpose of this study was to analyse the effects of demographic factors, clinical factors, and genetic polymorphisms of related gene loci on warfarin bleeding-related complications in the Han population.<br />Methods: Retrospective medical record review. The study cases were patients treated at the Fujian Medical University Union Hospital from March 2016 to February 2020, and all received regular warfarin anticoagulation treatment for at least 3 months, and were provided the initial standard dose and stable dose of warfarin.<br />Results: Data were collected from 451 qualifying patients (47% male, 53% female). The average age of patients was 53.8 ± 12.2 years, and the average body surface area was 1.6 ± 0.18 m <superscript>2</superscript> . There were nine major bleeding events and 141 minor bleeding events. In the univariate logistic analysis, the p-value of the four factors body weight, body surface area (BSA), amiodarone, and rs429358 was < 0.10. However, the final p-values for amiodarone and rs429358 were < 0.05 in the multifactorial logistic analysis.<br />Conclusions: The ApoE (rs429358) gene polymorphism influences bleeding complications in Chinese Han patients treated with warfarin. The sample size of this study was relatively small; hence an international study with a larger sample size is needed in the future.<br /> (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Adult
Aged
Amiodarone pharmacology
Anti-Arrhythmia Agents pharmacology
Body Surface Area
Body Weight
China
Cytochrome P-450 Enzyme Inhibitors pharmacology
Ethnicity
Female
Genotype
Humans
International Normalized Ratio
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
Sociodemographic Factors
Anticoagulants adverse effects
Apolipoproteins E genetics
Asian People genetics
Hemorrhage chemically induced
Warfarin adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1041
- Volume :
- 78
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34596727
- Full Text :
- https://doi.org/10.1007/s00228-021-03204-y