Back to Search Start Over

Cortical Frontoparietal Network Dysfunction in CHMP2B -Frontotemporal Dementia.

Authors :
Musaeus CS
Pedersen JS
Kjær TW
Johannsen P
Waldemar G
Haverberg MJN
Bacher T
Nielsen JE
Roos P
Source :
Frontiers in aging neuroscience [Front Aging Neurosci] 2021 Sep 13; Vol. 13, pp. 714220. Date of Electronic Publication: 2021 Sep 13 (Print Publication: 2021).
Publication Year :
2021

Abstract

A rare cause of inherited frontotemporal dementia (FTD) is a mutation in the CHMP2B gene on chromosome 3 leading to the autosomal dominantly inherited FTD ( CHMP2B -FTD). Since CHMP2B -FTD is clinically well-characterized, and patients show a distinct pattern of executive dysfunction, the condition offers possible insight in the early electroencephalographic (EEG) changes in the cortical networks. Specifically, EEG microstate analysis parses the EEG signals into topographies believed to represent discrete network activations. We investigated the EEG dynamics in patients with symptomatic CHMP2B -FTD ( n = 5) as well as pre-symptomatic mutation carriers ( n = 5) compared to non-carrier family members ( n = 6). The data was parsed into four archetypal microstates and global power was calculated. A trend was found for lower occurrence in microstate D in CHMP2B -FTD ( p- value = 0.177, F- value = 2.036). Patients with recent symptom onset (<1 year) showed an increased duration of microstate D, whereas patients who had been symptomatic for longer periods (>2 years) showed decreased duration. Patients with CHMP2B -FTD present with executive dysfunction, and microstate D has previously been shown to be associated with the fronto-parietal network. The biphasic pattern may represent the pathophysiological changes in brain dynamics during neurodegeneration, which may apply to other neurodegenerative diseases.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Musaeus, Pedersen, Kjær, Johannsen, Waldemar, Haverberg, Bacher, Nielsen, Roos and The FReJA Consortium.)

Details

Language :
English
ISSN :
1663-4365
Volume :
13
Database :
MEDLINE
Journal :
Frontiers in aging neuroscience
Publication Type :
Academic Journal
Accession number :
34588974
Full Text :
https://doi.org/10.3389/fnagi.2021.714220