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Azithromycin versus Amoxicillin and Malarial Parasitemia among Children with Uncomplicated Severe Acute Malnutrition: A Randomized Controlled Trial.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2021 Sep 27; Vol. 106 (1), pp. 351-355. Date of Electronic Publication: 2021 Sep 27. - Publication Year :
- 2021
-
Abstract
- Antibiotics are recommended by the WHO as part of the management of uncomplicated severe acute malnutrition in children. We evaluated whether azithromycin, an antibiotic with antimalarial properties, improved malarial parasitemia outcomes in children with severe acute malnutrition compared with amoxicillin, an antibiotic commonly used for severe acute malnutrition that does not have antimalarial properties. Total of 301 children were randomized (1:1) to a single oral dose of azithromycin or a 7-day course of amoxicillin and followed for 8 weeks. We found no significant evidence that children receiving azithromycin had improved parasitemia outcomes relative to amoxicillin. Although azithromycin may have advantages over amoxicillin in terms of dosing and administration for uncomplicated severe acute malnutrition, it may not yield additional benefit for malaria outcomes.
- Subjects :
- Burkina Faso
Child, Preschool
Humans
Infant
Malaria complications
Parasitemia drug therapy
Treatment Outcome
Amoxicillin therapeutic use
Anti-Infective Agents therapeutic use
Azithromycin therapeutic use
Child Nutrition Disorders complications
Infant Nutrition Disorders complications
Malaria drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 106
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 34583344
- Full Text :
- https://doi.org/10.4269/ajtmh.21-0595