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Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy.
- Source :
-
Scientific reports [Sci Rep] 2021 Sep 28; Vol. 11 (1), pp. 18722. Date of Electronic Publication: 2021 Sep 28. - Publication Year :
- 2021
-
Abstract
- Delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging requires novel and time-efficient approaches to characterize the myocardial substrate associated with ventricular arrhythmia in patients with ischemic cardiomyopathy. Using a translational approach in pigs and patients with established myocardial infarction, we tested and validated a novel 3D methodology to assess ventricular scar using custom transmural criteria and a semiautomatic approach to obtain transmural scar maps in ventricular models reconstructed from both 3D-acquired and 3D-upsampled-2D-acquired LGE-CMR images. The results showed that 3D-upsampled models from 2D LGE-CMR images provided a time-efficient alternative to 3D-acquired sequences to assess the myocardial substrate associated with ischemic cardiomyopathy. Scar assessment from 2D-LGE-CMR sequences using 3D-upsampled models was superior to conventional 2D assessment to identify scar sizes associated with the cycle length of spontaneous ventricular tachycardia episodes and long-term ventricular tachycardia recurrences after catheter ablation. This novel methodology may represent an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D LGE-CMR slices and automatic scar detection.<br /> (© 2021. The Author(s).)
- Subjects :
- Aged
Animals
Arrhythmias, Cardiac pathology
Cardiomyopathies metabolism
Cicatrix diagnostic imaging
Computational Biology methods
Contrast Media
Female
Gadolinium pharmacology
Heart Ventricles physiopathology
Humans
Image Processing, Computer-Assisted methods
Imaging, Three-Dimensional methods
Magnetic Resonance Imaging methods
Male
Middle Aged
Myocardial Infarction diagnostic imaging
Myocardial Infarction physiopathology
Myocardial Ischemia pathology
Myocardium pathology
Recurrence
Swine
Tachycardia, Ventricular physiopathology
Cardiomyopathies diagnostic imaging
Cicatrix pathology
Tachycardia, Ventricular diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 34580343
- Full Text :
- https://doi.org/10.1038/s41598-021-97399-w