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Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity.

Authors :
Ausderau K
Kabakov S
Razo E
Mitzey AM
Bach KM
Crooks CM
Dulaney N
Keding L
Salas-Quinchucua C
Medina-Magües LG
Weiler AM
Bliss M
Eickhoff J
Simmons HA
Mejia A
Antony KM
Morgan T
Capuano S 3rd
Schneider ML
Aliota MT
Friedrich TC
O'Connor DH
Golos TG
Mohr EL
Source :
Viruses [Viruses] 2021 Sep 20; Vol. 13 (9). Date of Electronic Publication: 2021 Sep 20.
Publication Year :
2021

Abstract

Infants exposed to Zika virus (ZIKV) prenatally may develop birth defects, developmental deficits, or remain asymptomatic. It is unclear why some infants are more affected than others, although enhancement of maternal ZIKV infection via immunity to an antigenically similar virus, dengue virus (DENV), may play a role. We hypothesized that DENV immunity may worsen prenatal ZIKV infection and developmental deficits in offspring. We utilized a translational macaque model to examine how maternal DENV immunity influences ZIKV-exposed infant macaque neurodevelopment in the first month of life. We inoculated eight macaques with prior DENV infection with ZIKV, five macaques with ZIKV, and four macaques with saline. DENV/ZIKV-exposed infants had significantly worse visual orientation skills than ZIKV-exposed infants whose mothers were DENV-naive, with no differences in motor, sensory or state control development. ZIKV infection characteristics and pregnancy outcomes did not individually differ between dams with and without DENV immunity, but when multiple factors were combined in a multivariate model, maternal DENV immunity combined with ZIKV infection characteristics and pregnancy parameters predicted select developmental outcomes. We demonstrate that maternal DENV immunity exacerbates visual orientation and tracking deficits in ZIKV-exposed infant macaques, suggesting that human studies should evaluate how maternal DENV immunity impacts long-term neurodevelopment.

Details

Language :
English
ISSN :
1999-4915
Volume :
13
Issue :
9
Database :
MEDLINE
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
34578459
Full Text :
https://doi.org/10.3390/v13091878